What Not to Take With Amox-Clav

What Not to Take With Amox-Clav

Amox-Clav, also known as Amoxicillin-Clavulanate or Augmentin, is an antibiotic used to treat various bacterial infections. It’s a combination of amoxicillin, a penicillin-like antibiotic, and clavulanate potassium, a substance that helps prevent certain bacteria from becoming resistant to amoxicillin. While Amox-Clav is effective in treating infections, it’s important to know that certain medications and substances can interact with it. In this article, we will discuss what not to take with Amox-Clav to ensure its effectiveness and prevent adverse effects.

1. Allopurinol

Allopurinol is a medication used to treat gout. Combining allopurinol with Amox-Clav can increase the risk of a skin rash. If you are taking allopurinol, it’s essential to inform your healthcare provider before starting Amox-Clav.

2. Warfarin and Other Blood Thinners

Warfarin is an anticoagulant used to prevent blood clots. Amox-Clav can enhance the effects of warfarin, increasing the risk of bleeding. Your doctor might need to adjust the dosage of warfarin if you need to take Amox-Clav.

3. Methotrexate

Methotrexate is a medication used to treat certain types of cancer or to control severe psoriasis or rheumatoid arthritis. Amox-Clav can interfere with the elimination of methotrexate from the body, which can result in increased side effects from methotrexate.

4. Oral Contraceptives

There is some evidence to suggest that antibiotics like Amox-Clav can reduce the effectiveness of oral contraceptives. While this is a topic of debate, it might be wise to use an additional form of contraception while taking Amox-Clav.

5. Probenecid

Probenecid, used to treat gout and to increase the effectiveness of certain antibiotics, can interact with Amox-Clav. This drug can decrease the elimination of amoxicillin from the body, increasing the levels of the antibiotic. This might require a dosage adjustment.

6. Alcohol

While moderate alcohol consumption is not necessarily contraindicated, it’s generally a good idea to avoid alcohol when taking antibiotics, including Amox-Clav. Alcohol can stress the liver and may exacerbate the side effects of antibiotics.

7. Specific Dietary Supplements

Certain dietary supplements, especially those containing calcium, magnesium, iron, or zinc, can reduce the absorption of antibiotics. It’s best to take Amox-Clav either two hours before or six hours after taking these supplements.

8. Antacids

Antacids containing aluminum or magnesium can reduce the absorption of Amox-Clav. Like dietary supplements, it’s best to take Amox-Clav two hours before or six hours after taking antacids.


Always inform your healthcare provider of all the medications and supplements you are taking before starting a new medication, including Amox-Clav. Follow the prescription and avoid any substances that your healthcare provider advises against.


When taking Amox-Clav, it’s essential to be aware of potential interactions with other medications and substances. This includes allopurinol, warfarin, methotrexate, oral contraceptives, probenecid, certain dietary supplements, and antacids. Always consult your healthcare provider for personalized medical advice and guidance when taking antibiotics, including Amox-Clav.