What is the Creatinine Level for Stage 4 Kidney Disease

Kidney disease, a gradual loss of kidney function over time, is categorized into five stages based on various factors. One essential factor used to determine the stage of kidney disease is the creatinine level in the blood. In this article, we’ll delve deep into understanding the creatinine level indicative of stage 4 kidney disease and its significance.

Understanding Creatinine

Creatinine is a waste product resulting from the normal wear and tear of muscles in the body. The kidneys, functioning as our body’s natural filtration system, are responsible for removing creatinine from the blood and excreting it through urine. Thus, the creatinine level in the bloodstream is a reliable indicator of kidney function.

Staging Kidney Disease with Creatinine

To assess the severity of kidney disease, healthcare professionals use the Glomerular Filtration Rate (GFR). This rate measures how much blood the kidneys filter per minute. GFR is determined using various factors, including age, gender, body size, and serum creatinine level.

Based on GFR, kidney disease is categorized into five stages:

  1. Stage 1: GFR >90 mL/min (Normal or high function)
  2. Stage 2: GFR 60-89 mL/min (Mild loss of function)
  3. Stage 3: GFR 30-59 mL/min (Moderate loss of function)
  4. Stage 4: GFR 15-29 mL/min (Severe loss of function)
  5. Stage 5: GFR <15 mL/min (Kidney failure or end-stage renal disease)

For stage 4 kidney disease, the GFR lies between 15 and 29 mL/min.

Creatinine Level for Stage 4

While GFR is a direct measure used to stage kidney disease, it’s calculated using the creatinine level. Generally, as the creatinine level rises, the GFR drops, indicating diminished kidney function.

For stage 4 kidney disease, the serum creatinine levels can vary, typically ranging from 2.0 mg/dL to 5.0 mg/dL in most adults, although this can be influenced by factors like muscle mass and age.

Implications of Stage 4 Kidney Disease

At stage 4:

  • Kidney damage is severe.
  • There’s a heightened risk of heart diseases.
  • Anemia, bone disease, and malnutrition might develop.
  • Preparations for kidney replacement therapy (dialysis) or kidney transplant might begin.

Managing and Monitoring

It’s imperative to regularly monitor creatinine and GFR levels. Management may involve:

  • Medications to control blood pressure and protect the kidneys.
  • Dietary adjustments to limit protein, phosphorus, and potassium.
  • Avoidance of nephrotoxic drugs.


  1. How often should I get my creatinine levels checked if I have kidney disease?
    Regular check-ups, as advised by your nephrologist, are essential, typically every 3-6 months, depending on disease severity.
  2. Are there other factors besides creatinine used to determine kidney disease stages?
    Yes, symptoms, overall health, and results of urine tests can also be considered.
  3. Can I reverse stage 4 kidney disease?
    While reversing the damage might not be possible, proper management can slow disease progression.
  4. Are there symptoms associated with elevated creatinine levels?
    High creatinine levels may not cause symptoms. However, symptoms of kidney disease might include fatigue, swelling, or urinary changes.
  5. Can diet influence creatinine levels?
    A diet high in red meat can temporarily increase creatinine levels. A balanced, kidney-friendly diet is recommended for those with kidney disease.


Understanding creatinine levels and its association with kidney disease staging provides valuable insights into kidney function and potential interventions. While stage 4 kidney disease is severe, with timely and appropriate management, the progression can be slowed, leading to an improved quality of life.