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Personalized & Precise genetic approach to Prostate Cancer

Long Story Short
  • BRCA 1/2 and ATM genetic mutations increase the risk for aggressive prostate cancer (CaP)
  • We don’t have a great way are detecting aggressive CaP
  • These mutations can be easily assessed with Opus23 (using your 23andMe info)
 
Personalized and Precise Medicine, that’s how I work. And now we can make prostate cancer (CaP) screening even more personalized.
 
Ever heard of the BRCA mutation (the reason why Angelina Jolie had a double mastectomy)? Well now BRCA mutations give insight into the risk of aggressive prostate cancer.
 
A new study out of the European Urology found that men who had a BRCA1, BRCA2 and ATM gene mutations were at a higher risk of a more deadly, aggressive form of prostate cancer. In fact these mutations were found 5-fold higher in those with lethal CaP.
 
The men with these mutations were diagnosed with a more aggressive cancer at a younger age and had a shorter survival time (4yrs vs. 8yrs).
 

Bottom line:


Common treatment plans for prostate cancer often leave men with urinary incontinence and erectile dysfunction. The other options is Active Surveillance, where the cancer isn’t aggressive yet but the patient is monitored closely with PSA, biopsy and MRI scans to make sure it doesn’t become lethal.
 
Yet with genetic information we be more precise and more personalized in how we approach men with prostate cancer. Perhaps if you don’t have these mutations, active surveillance WITH natural preventive treatments might be the best option.
 
*There are other genes involved with lethal prostate cancer such as CHEK2 (also found in Opus23) which plays into the whole equation.
Reference:
  1. Rong Na, S. Lilly Zheng, Misop Han, Hongjie Yu, et al.  Germline Mutations in ATM and BRCA1/2 Distinguish Risk for Lethal and Indolent Prostate Cancer and are Associated with Early Age at DeathEuropean Urology, 2016; DOI: 10.1016/j.eururo.2016.11.033
  2. https://www.sciencedaily.com/releases/2016/12/161215125905.htm
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